The reversal of PABA of sulfonamide inhibition of the viruses of lymphogranuloma venereum and mouse pneumonitis.

نویسندگان

  • C T HUANG
  • M D EATON
چکیده

The antagonism of para-aminobenzoic acid (PABA) to the chemotherapeutic action of sulfonamides in vitro and in vivo has long been established by various workers (McCarty, 1941; Selbie, 1940; Thomas and Dingle, 1942; Woods, 1940). The studies of Woods and Fildes (Fildes, 1940; Woods, 1940; Woods and Fildes, 1940) provided, furthermore, a hypothetical picture of the metabolism of bacteria, based on the competitive antagonism of these two chemicals. The antagonism has also been extended to a sulfonamide-susceptible fungus by Dimond (1941) and malaria parasites by Seeler et al. (1943). The discovery of the chemotherapeutic action of sulfonamides on the lumphogranuloma venereum (LGV) virus (Felton et al., 1943; Findlay, 1940a,b; MacCallum and Findlay, 1938; McKee et al., 1942; Rodaniche, 1942) has led workers to investigate whether this antagonistic phenomenon ofPABA and the sulfonamides could be applied to this sulfonamide-susceptible virus (Findlay, 1940; Rodaniche, 1942; Seeler et al., 1943). However, the work was controversial. Findlay (1940), feeding 10 mg sulfanilamide and 10 mg PABA suspended in gum acacia to mice, found that PABA antagonized the chemotherapeutic action of sulfanilamide for the LGV virus injected intracerebrally. His finding was based on the development of symptoms and the death rate in mice. In contrast to Findlay's finding, Seeler et al. (1943), using a diet containing 0.3 per cent, 0.03 per cent sulfanilamide and 0.3 per cent PABA, respectively, in one experiment, and 0.03 per cent sulfamethyldiazine and 0.3 per cent PABA in another, found that PABA showed no antagonistic action in mice that had previously been infected by the intracerebral route with their strain of the LVG virus. Their finding was based on the percentage of survivors 28 days after the infection. Rodaniche (1943) fed a diet containing 2 per cent sulfathiazole and 0.5 per cent PABA to intracerebrally infected mice and found no evidence of reversal at this ratio. However, when he used an equal amount of the two chemicals together, he found that the PABA exerted some antagonistic action. After the discovery that the 6BC strain of the psittacosis virus was susceptible to sulfadiazine (Early and Morgan, 1946a,b), Morgan (1948a,b) found that PABA definitely antagonized the chemotherapeutic action of sulfadiazine on this virus in eggs and that the chemotherapeutic action of the sulfadiazine was also reversed by pteroic acid and pteroylglutamic acid. He postulated that sulfadiazine prevented the growth of the 6BC strain of psittacosis virus by interfering with its use of the PABA in the synthesis of pteroylglutamic acid.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Lymphogranuloma venereum. II. Characterization of some recently isolated strains.

Five Bedsonia (Chlamydia) isolates from lymphogranuloma venereum (LGV) patients were tested for inclusion type, sulfonamide sensitivity, and mouse virulence. Two matched the classical description of LGV agents. Two were not virulent for mice by the intracerebral route, therefore fitting the description for trachoma-inclusion conjunctivitis agents. One was highly virulent for mice and sulfonamid...

متن کامل

The Antigenic Relationship of the Viruses of Meningopneumonitis and Lymphogranuloma Venereum

Animals recovered from infection with the viruses of lymphogranuloma venereum, meningopneumonitis, and psittacosis, were reinoculated in crossimmunity tests with these viruses. In mice immunized by intracerebral or intranasal inoculation a reciprocal partial cross-immunity between the viruses of lymphogranuloma venereum and meningopneumonitis was demonstrated. In preliminary experiments, simila...

متن کامل

The Effect of Para-Aminobenzoic Acid on the Chemotherapeutic Activity of the Sulfonamides in Lymphogranuloma Venereum and in Duck Malaria.

It is now well established that para-aminobenzoic acid inhibits the action of sulfonamides on bacteria in vitro and in vivo .(Rubbo and Gillespie, 1940; Selbie, 1940; Woods, 1940). Wiedling (1941) found that para-aminobenzoic acid produced an inhibition of the effect of sulfanilamide, sulfapyridine and sulfathiazole on the fresh water diatom Nitzschia palea var. debilis. Experiments published b...

متن کامل

Aureomycin in the treatment of granuloma inguinale and lymphogranuloma venereum.

Physicians have long searched for an effective therapeutic agent against the unusually resistant diseases, granuloma inguinale and lymphogranuloma yenereum. Chancroid responds readily to antiseptic measures and the sulfonamide compounds. Syphilis is controlled by penicillin or arsenicals and bismuth compounds. Gonorrhea responds to the sulfonamides, penicillin or streptomycin. The discovery tha...

متن کامل

Can Chemotherapy Be Extended to Include the Intracellular Disease Agents?

The present limits of successful chemotherapy do not quite coincide with the line of division between extracellular and intracellular disease agents. Thus chemotherapeutic benefit in experimental murine typhus has recently been reported by Moragues, Pinkerton, and Greiff (1944), and in human epidemic typhus by Yeomans and others (1944). Chemotherapeutic benefit is well authenticated for infecti...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Journal of bacteriology

دوره 58 1  شماره 

صفحات  -

تاریخ انتشار 1949